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Beyond M100: Why CLSI M45 is the Clinical Lab’s Secret Weapon
CLSI M45 is a document that provides guidelines for the performance and interpretation of antimicrobial susceptibility testing (AST) of fungi, including yeast and molds. The document is intended for clinical microbiologists, laboratory professionals, and healthcare providers.
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Standardizing AST for these rare bugs is a growing challenge. Studies show that using "non-standardized" methods (anything not specified in M45) can lead to inconsistent results, which is a major hurdle in combating antimicrobial resistance .
The 3rd Edition (M45-Ed3) brought several significant updates designed to modernize laboratory practice:
The CLSI M45 document, titled "Guidance for Antimicrobial Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria," is a specialized publication designed for clinical laboratory scientists, pathologists, and infectious disease specialists. This public link is valid for 7 days
Standard Mueller-Hinton Agar (MHA) or Mueller-Hinton Broth (MHB) is frequently insufficient. M45 mandates specific supplements, such as:
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The CLSI M45 document covers the following topics:
Often isolated from animal bite wounds. 2. Gram-Positive Bacilli
The Clinical and Laboratory Standards Institute (CLSI) addresses this challenge through the . This standard provides vital, actionable guidance for antimicrobial susceptibility testing (AST) of infrequently isolated or fastidious bacteria.